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Thapsigargin [67526-95-8]
Katalog-Nummer 10-2105-1mg
Size : 1mg
Marke : Focus Biomolecules
Contact local distributor :
Telefonnummer : +1 850 650 7790
Thapsigargin | SERCA inhibitor
CAS:
67526-95-8
Catalog Number:
10-2105
Activity:
SERCA inhibitor
Chemical Name:
Isolated from Thapsia garganica
Molecular Weight:
650.77
Molecular Formula:
C34H50O12
Solubility:
Soluble in DMSO (up to 65 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Colorless waxy solid / film
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT
Thapsigargin (67526-95-8) is a potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase.1 (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines.2 Warning: Thapsigargin is highly irritating to skin and mucus membranes.
References/Citations:
1) Treiman et al. (1998), A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases; Trends Pharmacol. Sci., 19 131
2) Zhou et al. (2009), Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance; Mol. Pharmacol., 76 596
CAS:
67526-95-8
Catalog Number:
10-2105
Activity:
SERCA inhibitor
Chemical Name:
Isolated from Thapsia garganica
Molecular Weight:
650.77
Molecular Formula:
C34H50O12
Solubility:
Soluble in DMSO (up to 65 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Colorless waxy solid / film
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee
Thapsigargin (67526-95-8) is a potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase.1 (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines.2 Warning: Thapsigargin is highly irritating to skin and mucus membranes.
References/Citations:
1) Treiman et al. (1998), A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases; Trends Pharmacol. Sci., 19 131
2) Zhou et al. (2009), Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance; Mol. Pharmacol., 76 596
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