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17-AAG [75747-14-7]
Katalog-Nummer 10-1097-1mg
Size : 1mg
Marke : Focus Biomolecules
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Telefonnummer : +1 850 650 7790
17-AAG | HSP90 inhibitor
CAS:
75747-14-7
Catalog Number:
10-1097
Activity:
HSP90 inhibitor
Chemical Name:
17-(Allylamino)-17-desmethoxygeldanamycin
Molecular Weight:
585.7
Molecular Formula:
C31H43N3O8
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Purple or dark red solid
Purity:
>98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
17-AAG (75747-14-7) is a semi-synthetic analog of geldanamycin (Cat.# 10-1084) which is less toxic and more stable. 17-AAG selectively binds to and inhibits HSP90 from tumor cells. Anti-angiogenic activity. Cell permeable.
References/Citations:
1) Schulte et al. (1998), The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin; Cancer Chemother. Pharmacol. 42 273
2) Kamal et al. (2003), A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors; Nature, (b>425 407
3) Kaur et al. (2004), Therapeutic and diagnostic implications of Hsp90 activation; Clinical Cancer Res. 10 4813
CAS:
75747-14-7
Catalog Number:
10-1097
Activity:
HSP90 inhibitor
Chemical Name:
17-(Allylamino)-17-desmethoxygeldanamycin
Molecular Weight:
585.7
Molecular Formula:
C31H43N3O8
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Purple or dark red solid
Purity:
>98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee
17-AAG (75747-14-7) is a semi-synthetic analog of geldanamycin (Cat.# 10-1084) which is less toxic and more stable. 17-AAG selectively binds to and inhibits HSP90 from tumor cells. Anti-angiogenic activity. Cell permeable.
References/Citations:
1) Schulte et al. (1998), The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin; Cancer Chemother. Pharmacol. 42 273
2) Kamal et al. (2003), A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors; Nature, (b>425 407
3) Kaur et al. (2004), Therapeutic and diagnostic implications of Hsp90 activation; Clinical Cancer Res. 10 4813
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