| Primary Accession | P55061 |
|---|---|
| Clone Names | 90805117 |
| Gene ID | 7009 |
|---|---|
| Other Names | Bax inhibitor 1, BI-1, Testis-enhanced gene transcript protein, Transmembrane BAX inhibitor motif-containing protein 6, TMBIM6, BI1, TEGT |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TMBIM6 |
|---|---|
| Synonyms | BI1, TEGT |
| Function | Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Highly abundant in testis. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
TMBIM6 is a suppressor of apoptosis.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Lee, G.H., et al. Mol. Cell. Biol. 30(7):1800-1813(2010)Zhang, M., et al. Mol. Cell. Biochem. 333 (1-2), 1-7 (2010) :Kotsafti, A., et al. BMC Gastroenterol 10, 35 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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Cat# BP18137b