SS18 Break Apart FISH Probe, Dye Color: Green-Orange

Our SS18 break apart probe is designed to detect SS18 translocations. The probe comes labeled in green and orange, but can be customized to meet your needs. 

Gene Background: SS18 is frequently rearranged in synovial sarcoma, an aggressive neoplasm accounting for 10-20% of soft tissue sarcomas in the adolescent and young adult population. Approximately 70% of cases present in the extremities, with a tendency to metastasize to the lungs. The balanced chromosomal translocation t(X,18; p11,q11) is present in virtually all cases of synovial sarcoma. The rearrangement creates an in-frame fusion of the SS18 gene to SSX1 or SSX2, whereby all but the C-terminal eight amino acids of SS18 become fused to the C-terminal 78 amino acids of the SS18 partner. An analogous translocation of SSX4 is present in less than 1% of cases. SS18-SSX fusion is the sole cytogenetic abnormality in up to a third of synovial sarcomas, and is now considered a central driver of the disease.

Source: Nielsen T, et al. (2015) Cancer discovery 5.2: 124-134.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.