Quilseconazole [1340593-70-5]
Katalog-Nummer HY-109040-25mg
Size : 25mg
Marke : MedChemExpress
Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
Quilseconazole Chemische Struktur
CAS. Nr. : 1340593-70-5
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen:
Beschreibung |
Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes[1]. |
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IC50 & Target |
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Cellular Effect |
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Molekulargewicht |
513.37 |
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Formel |
C22H14F7N5O2 |
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CAS. Nr. |
1340593-70-5 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O[C@@](CN1C=NN=N1)(C(C=CC(F)=C2)=C2F)C(F)(C3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=N3)F |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : 100 mg/mL (194.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation |
Purity: 98.98% |
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Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.9479 mL | 9.7396 mL | 19.4791 mL | 48.6978 mL |
5 mM | 0.3896 mL | 1.9479 mL | 3.8958 mL | 9.7396 mL | |
10 mM | 0.1948 mL | 0.9740 mL | 1.9479 mL | 4.8698 mL | |
15 mM | 0.1299 mL | 0.6493 mL | 1.2986 mL | 3.2465 mL | |
20 mM | 0.0974 mL | 0.4870 mL | 0.9740 mL | 2.4349 mL | |
25 mM | 0.0779 mL | 0.3896 mL | 0.7792 mL | 1.9479 mL | |
30 mM | 0.0649 mL | 0.3247 mL | 0.6493 mL | 1.6233 mL | |
40 mM | 0.0487 mL | 0.2435 mL | 0.4870 mL | 1.2174 mL | |
50 mM | 0.0390 mL | 0.1948 mL | 0.3896 mL | 0.9740 mL | |
60 mM | 0.0325 mL | 0.1623 mL | 0.3247 mL | 0.8116 mL | |
80 mM | 0.0243 mL | 0.1217 mL | 0.2435 mL | 0.6087 mL | |
100 mM | 0.0195 mL | 0.0974 mL | 0.1948 mL | 0.4870 mL |
Quilseconazole Related Classifications
- Anti-infection Metabolic Enzyme/Protease
- Fungal Cytochrome P450