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> IDE2 (1DE 2, Inducer of Definitive Endoderm 2)

IDE2 (1DE 2, Inducer of Definitive Endoderm 2)

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Katalog-Nummer 366890-10mg

Size : 10mg

Marke : US Biological

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366890 IDE2 (1DE 2, Inducer of Definitive Endoderm 2)

Clone Type
Polyclonal
Grade
Highly Purified
Shipping Temp
Blue Ice
Storage Temp
-20°C

Synonyms:|1DE 2, Inducer of Definitive Endoderm 2||Chemical Name:|Heptanedioic acid-1-(2-cyclopentylidenehydrazide) ||Molecular Formula: |C12 H20 N2O3||Molecular Weight:|240.3||CAS Number: |1136466-93-7||Purity: |≥98%||Applications: |FA||Appearance: Crystalline solid||Description:|IDE2 activates the TGF-beta signaling pathway and induces definitive endoderm formation in human and mouse embryonic stem cells. It is also reported to increase the levels of Nodal expression, induce Smad2 phosphorylation and SOX17 expression.||Storage:|Soluble in organic solvents such as ethanol and DMSO. DMSO up to 100mM.

Applications
Purity: Highly Purified (~98%)|Concentration: Not determined |Form: Supplied as a crystalline solid. ||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Form
Supplied as a crystalline solid.
Purity
Highly Purified (~98%)
References
1. Borowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., Melton, D. A. (2009). Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell stem cell, 4(4), 348-358. 2. Li, W., Ding, S. (2010). Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends in pharmacological sciences, 31(1), 36-45.|3. Aguayo-Mazzucato, C., Bonner-Weir, S. (2010). Stem cell therapy for type 1 diabetes mellitus. Nature Reviews Endocrinology, 6(3), 139-148.