Hyaluronic acid [9004-61-9]
Katalog-Nummer T3762-1g
Size : 1g
Marke : TargetMol
Hyaluronic acid
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Hyaluronic acid
Catalog No. T3762Cas No. 9004-61-9
Hyaluronic acid (hyaluronan) is a glucosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units that is a component of connective tissue, skin, vitreous humour, umbilical cord, synovial fluid and the capsule of certain microorganisms contributing to adhesion, elasticity, and viscosity of extracellular substances.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
Description | Hyaluronic acid (hyaluronan) is a glucosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units that is a component of connective tissue, skin, vitreous humour, umbilical cord, synovial fluid and the capsule of certain microorganisms contributing to adhesion, elasticity, and viscosity of extracellular substances. |
In vitro | Hyaluronic acid (HA) is extensively utilized across various medical fields due to its capacity to bind with numerous water molecules, thereby enhancing tissue hydration and mechanical resistance. Its significant roles include facilitating wound healing, ovulation, fertilization, signal transduction, and impacting tumor physiology, making it valuable in aesthetic medicine, joint disorder treatments like osteoarthritis and rheumatoid arthritis, and ophthalmology for its lubricative benefits on the corneal endothelium. High molecular mass HA impairs the chemotaxis and migration of inflammatory cells, thus serving as an effective barrier to inflammation and shielding from free radicals. Furthermore, HA contributes to aesthetic dermatology by minimizing mechanical damage to tissues with minimal side effects. Research also suggests its potential in identifying tumor markers, managing liver diseases, and application in pharmaceutical formulations. In cancer research, particularly digestive cancers, HA interactions with tumor cells may activate signaling pathways that promote proliferation, cell adhesion, migration, invasion, and contribute to angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like characteristics, and resistance to chemotherapy and radiation. |
In vivo | HA (hyaluronic acid) is ubiquitous across biological fluids and tissues, with its beneficial effects on joint health evidenced by numerous animal studies. These studies have demonstrated that HA enhances cartilage matrix synthesis, prevents its degradation, mitigates inflammation, fosters the production of endogenous HA, and augments cartilage resilience and hydration. Additionally, topically applied high molecular weight HA formulations have been shown to expedite the healing of acute skin wounds and facilitate the recovery of venous leg ulcers, thereby offering a valuable option for chronic wound management. |
Alias | Hyaluronate, hyaluronan |
Molecular Weight | 800000~1500000 |
Formula | (C14H21NO11)n |
Cas No. | 9004-61-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | H2O: 14.29 mg/mL |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
InhibitorinhibitHyaluronic acidEndogenous Metabolite