Guinea pig Polyclonal Anti-Keratin K8
Katalog-Nummer 03-GP-K8-25ul
Size : 25ul
Marke : American Research Products
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Telefonnummer : +1 850 650 7790
Anti-Keratin K8 Polyclonal Antibody
Category: Antibodies
Catalog
03-GP-K8
| Product Name | Anti-Keratin K8 Polyclonal Antibody |
|---|---|
| Description | This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. |
| Synonyms | K8, KO, CK8, CK-8, CYK8, K2C8, CARD2 |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide (C-MSIRVTQKSYKVST) of human keratin K8 (formerly also designated cytokeratin 8), coupled to KLH |
| Specificity | Basic human keratin K8 (Mr 52 000) of all simple type and complex epithelia. Specific for keratin K8. Marker for discrimination of simple / non-stratified epithelia from those of stratified origin. |
| Reactivity | Human, Mouse |
| Applications | IHC, WB |
| Form | Stabilized Serum |
| Storage | 2-8C |
| References | Moll, R. et al. (1982) Cell 31: 11-24 |
| Background | This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. |
| Supplier | ARP |
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