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> Growth Hormone Releasing Factor, Human (GHRF, GHRH)

Growth Hormone Releasing Factor, Human (GHRF, GHRH)

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Katalog-Nummer G9000-19R-1mg

Size : 1mg

Marke : US Biological

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G9000-19R Growth Hormone Releasing Factor, Human (GHRF, GHRH)

Clone Type
Polyclonal
Grade
Highly Purified
Shipping Temp
RT
Storage Temp
-20°C

Synthetic Human GHRH is a single, non-glycosylated, polypeptide chain containing 29 amino acids and having a molecular mass of 335D Dalton. Corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone consisting of 44 amino acid residues.||Amino Acid Sequence:|The free base of sermorelin has the empirical formula C149H246N44O42S.|Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2.||Biological Activity:|HuGHRH increases plasma growth hormone concentrations by directly stimulating the anterior pituitary gland to release natural human growth hormone.||Storage and Stability:|Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O or 1% acetic acid. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Applications
Source: Synthetic|Purity: ≥98% by RP-HPLC and SDS-PAGE. Chromatographically purified.|Form: Supplied as a lyophilized powder from sodium phosphate monobasic, sodium phosphate dibasic. Reconstitute with sterile ddH2O to a concentration ≥0.1mg/ml. GHRH can also be diluted in 1% acetic acid at a concentration of 1mg/ml.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Form
Supplied as a lyophilized powder from sodium phosphate monobasic, sodium phosphate dibasic. Reconstitute with sterile ddH2O to a concentration ≥0.1mg/ml. GHRH can also be diluted in 1% acetic acid at a concentration of 1mg/ml.
Purity
≥98% by RP-HPLC and SDS-PAGE. Chromatographically purified.
References
1. Increased body weight via injecting myogenic expression growth hormone-releasing hormone (GHRH) plasmid DNA into sheep. Meng QY, Chen ZQ, Xie QF, Anim Biotechnol 2004;15(2):175-92. 2. Blockade of endogenous growth hormone-releasing hormone receptors dissociates nocturnal growth hormone secretion and slow-wave sleep. Jessup SK, Malow BA, Barkan AL, Eur J Endocrinol 2004 Nov;151(5):561-6. 3. Acromegaly caused by ectopic growth hormone-releasing hormone secretion by a carcinoid bronchial tumor: a rare entity. Athanassiadi K, Exarchos D, Bellenis I, J Thorac Cardiovasc Surg 2004 Oct;128(4):631-2. 4. Suppression of growth of H-69 small cell lung carcinoma by antagonists of growth hormone releasing hormone and bombesin is associated with an inhibition of protein kinase C signaling. Kanashiro CA, Schally AV, Hammann BD, Int J Cancer 2004 Nov 20;112(4):570-6. 5. Growth hormone releasing hormone reverses endotoxin-induced localized inflammatory hyperalgesia without reducing the upregulated cytokines, nerve growth factor and gelatinase activity. Talhouk RS, Saade NE, Masaad CA, Prog Neuropsychopharmacol Biol Psychiatry 2004 Jul;28(4):625-31. 6. Growth hormone-releasing hormone in HIV-infected men with lipodystrophy: a randomized controlled trial. Koutkia P, Canavan B, Torriani M, JAMA 2004 Jul 14;292(2):210-8.