GOT1 inhibitor-1 [732973-87-4]
Katalog-Nummer HY-122723-5mg
Size : 5mg
Marke : MedChemExpress
GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
GOT1 inhibitor-1 Chemische Struktur
CAS. Nr. : 732973-87-4
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Beschreibung |
GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC)[1]. |
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In Vitro |
PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research. In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC50 value of 8.2 uM[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molekulargewicht |
354.83 |
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Formel |
C19H19ClN4O |
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CAS. Nr. |
732973-87-4 |
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Unlabeled CAS |
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Appearance |
Solid |
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Color |
Off-white to light yellow |
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SMILES |
O=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=C(Cl)C=C4 |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : 125 mg/mL (352.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation |
Purity: 99.45% |
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Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.8183 mL | 14.0913 mL | 28.1825 mL | 70.4563 mL |
5 mM | 0.5637 mL | 2.8183 mL | 5.6365 mL | 14.0913 mL | |
10 mM | 0.2818 mL | 1.4091 mL | 2.8183 mL | 7.0456 mL | |
15 mM | 0.1879 mL | 0.9394 mL | 1.8788 mL | 4.6971 mL | |
20 mM | 0.1409 mL | 0.7046 mL | 1.4091 mL | 3.5228 mL | |
25 mM | 0.1127 mL | 0.5637 mL | 1.1273 mL | 2.8183 mL | |
30 mM | 0.0939 mL | 0.4697 mL | 0.9394 mL | 2.3485 mL | |
40 mM | 0.0705 mL | 0.3523 mL | 0.7046 mL | 1.7614 mL | |
50 mM | 0.0564 mL | 0.2818 mL | 0.5637 mL | 1.4091 mL | |
60 mM | 0.0470 mL | 0.2349 mL | 0.4697 mL | 1.1743 mL | |
80 mM | 0.0352 mL | 0.1761 mL | 0.3523 mL | 0.8807 mL | |
100 mM | 0.0282 mL | 0.1409 mL | 0.2818 mL | 0.7046 mL |