Reagenzien und Instrumente für die Immunologie Zellbiologie und Molekularbiologie
 
> Cyclic AMP [60-92-4]

Cyclic AMP [60-92-4]

Drucken Drucken
Melden Sie sich an

Katalog-Nummer HY-B1511-1g

Size : 1g

Marke : MedChemExpress

Contact local distributor :


Telefonnummer : +1 850 650 7790

Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Cyclic AMP Chemische Struktur

Cyclic AMP Chemische Struktur

CAS. Nr. : 60-92-4

This product is a controlled substance and not for sale in your territory.

Based on 6 publication(s) in Google Scholar

Other Forms of Cyclic AMP:

  • Cyclic AMP sodium In-stock
  • Cyclic AMP-13C5 Angebot einholen
Beschreibung

Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes[1][2][3].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

Cyclic AMP (Cyclic adenosine monophosphate) modulates mediator generation. Cyclic AMP suppresses the expression of pro-inflammatory cytokines, including TNF-α and IL-12, and enhances the production of the anti-inflammatory cytokine IL-10.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclic AMP Related Antibodies
Klinische Studie
Molekulargewicht

329.21

Formel

C10H12N5O6P
CAS. Nr.

60-92-4
Appearance

Solid

Color

White to off-white

SMILES

NC1=C2N=CN([C@@H]3O[C@]4(20)COP(O)(O[C@@]4(20)[C@H]3O)=O)C2=NC=N1
Structure Classification
  • Others
Initial Source
  • Microorganisms
  • Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

0.1 M NaOH : 30 mg/mL (91.13 mM; ultrasonic and adjust pH to 6 with NaOH)

H2O : 2.4 mg/mL (7.29 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0376 mL 15.1879 mL 30.3757 mL
5 mM 0.6075 mL 3.0376 mL 6.0751 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation

Purity: 99.94%

COA (256 KB) HNMR (123 KB) LCMS (109 KB)

Handling Instructions (2659 KB)
Verweise

  • [1]. G M Fimia, et al. Cyclic AMP signaling. J Cell Sci. 2001 Jun;114(Pt 11):1971-2.  [Content Brief]

    [2]. Paolo Sassone-Corsi, et al. The cyclic AMP pathway. Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12):a011148.  [Content Brief]

    [3]. Aronoff DM, et, al. Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis. J Interferon Cytokine Res. 2006 Nov;26(11):827-33.  [Content Brief]

  • [1]. G M Fimia, et al. Cyclic AMP signaling. J Cell Sci. 2001 Jun;114(Pt 11):1971-2.

    [2]. Paolo Sassone-Corsi, et al. The cyclic AMP pathway. Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12):a011148.

    [3]. Aronoff DM, et, al. Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis. J Interferon Cytokine Res. 2006 Nov;26(11):827-33.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 0.1 M NaOH 1 mM 3.0376 mL 15.1879 mL 30.3757 mL 75.9394 mL
5 mM 0.6075 mL 3.0376 mL 6.0751 mL 15.1879 mL
0.1 M NaOH 10 mM 0.3038 mL 1.5188 mL 3.0376 mL 7.5939 mL
15 mM 0.2025 mL 1.0125 mL 2.0250 mL 5.0626 mL
20 mM 0.1519 mL 0.7594 mL 1.5188 mL 3.7970 mL
25 mM 0.1215 mL 0.6075 mL 1.2150 mL 3.0376 mL
30 mM 0.1013 mL 0.5063 mL 1.0125 mL 2.5313 mL
40 mM 0.0759 mL 0.3797 mL 0.7594 mL 1.8985 mL
50 mM 0.0608 mL 0.3038 mL 0.6075 mL 1.5188 mL
60 mM 0.0506 mL 0.2531 mL 0.5063 mL 1.2657 mL
80 mM 0.0380 mL 0.1898 mL 0.3797 mL 0.9492 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Cyclic AMP Related Classifications

  • Metabolic Enzyme/Protease
  • Endogenous Metabolite
Help & FAQs

Keywords:

Cyclic AMP60-92-4Cyclic adenosine monophosphate Adenosine cyclic 3', 5'-monophosphate cAMPEndogenous Metabolitesecond messengerbiological processesderivativeadenosine triphosphatesignal transductionInhibitorinhibitorinhibit

Sie könnten auch an folgenden Produkten interessiert sein:



Katalog-Nummer
Beschreibung
Cond.
Preis zzgl. MwSt.
TRC-R417500-5G
D-Ribose [50-69-1]
 5g