B6567-10mg | CNQX disodium salt [479347-85-8] Biotrend

CNQX disodium salt is an antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate receptors, with IC50 values of 0.3 and 1.5 μM, respectively [1].

AMPA and kainate receptors, collectively referred to as non-N-methyl-D-aspartate receptors, are distinct receptor complexes, but activated by the same agonists. AMPA and kainate receptors are involved in rapidly desensitizing responses in central nervous system [2].

In thalamic reticular nucleus neurons, CNQX (20 μM) depolarized all cells tested in a similar manner as DNQX. With longer CNQX application (5 min vs. 1 min), the depolarization persisted throughout CNQX application. However, in ventrobasal neurons, CNQX (20 μM) produced negligible effects on the membrane potential [3].

In Sprague-Dawley rats, pretreatment with CNQX (0.02, 0.1, 0.6, 3 and 15 mg/kg), administered intraperitoneally 15 min before capsaicin, significantly reduced c-fos-labelled cells within trigeminal nucleus caudalis by a maximum of 45%. The number of c-fos-like immunoreactivity cells within lateral reticular, medullary reticular, and solitary tract nuclei was not affected [4].

References:

[1]. Honoré T, Davies S N, Drejer J, et al. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science, 1988, 241(4866): 701-703.

[2]. Bettler B, Mulle C. AMPA and kainate receptors. Neuropharmacology, 1995, 34(2): 123-139.

[3]. Lee S H, Govindaiah G, Cox C L. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. Journal of Neurophysiology, 2010, 103(4): 1728-1734.

[4]. Mitsikostas D D, Sanchez del Rio M, Waeber C, et al. Non-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis. British Journal of Pharmacology, 1999, 127(3): 623-630.

Physical Appearance	A solid
Storage	Desiccate at RT
M.Wt	276.12
Cas No.	479347-85-8
Formula	C₉H₂N₄O₄Na₂
Solubility	≥27.6 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
Chemical Name	sodium 6-cyano-7-nitroquinoxaline-2,3-bis(olate)
SDF	Download SDF
Canonical SMILES	[O-]C(N=C(C=C1[N+]([O-])=O)C(C=C1C#N)=N2)=C2[O-].[Na+].[Na+]
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Purity = 99.17%

Chemical structure

CNQX disodium salt [479347-85-8]

Katalog-Nummer B6567-10mg

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Marke : APExBIO Technology

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Background

Chemical Properties

Quality Control

Chemical structure

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