Briciclib [865783-99-9]
Katalog-Nummer HY-16366-1mg
Size : 1mg
Marke : MedChemExpress
Contact local distributor :
Telefonnummer : +1 850 650 7790
Briciclib (ON 014185) is a derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
Briciclib Chemische Struktur
CAS. Nr. : 865783-99-9
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Briciclib:
- ON-013100 In-stock
| Beschreibung |
Briciclib (ON 014185) is a derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers. |
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| IC50 & Target |
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| In Vitro |
Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| Klinische Studie |
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| Molekulargewicht |
474.42 |
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| Formel |
C19H23O10PS |
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| CAS. Nr. |
865783-99-9 |
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| Unlabeled CAS |
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| Appearance |
Solid |
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| Color |
White to off-white |
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| SMILES |
O=S(CC1=CC(OP(O)(O)=O)=C(OC)C=C1)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O |
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| Versand | Room temperature in continental US; may vary elsewhere. |
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| Speicherung |
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| Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : ≥ 31 mg/mL (65.34 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
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| Reinheit & Dokumentation |
Purity: 99.63 |
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| Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1078 mL | 10.5392 mL | 21.0784 mL | 52.6959 mL |
| 5 mM | 0.4216 mL | 2.1078 mL | 4.2157 mL | 10.5392 mL | |
| 10 mM | 0.2108 mL | 1.0539 mL | 2.1078 mL | 5.2696 mL | |
| 15 mM | 0.1405 mL | 0.7026 mL | 1.4052 mL | 3.5131 mL | |
| 20 mM | 0.1054 mL | 0.5270 mL | 1.0539 mL | 2.6348 mL | |
| 25 mM | 0.0843 mL | 0.4216 mL | 0.8431 mL | 2.1078 mL | |
| 30 mM | 0.0703 mL | 0.3513 mL | 0.7026 mL | 1.7565 mL | |
| 40 mM | 0.0527 mL | 0.2635 mL | 0.5270 mL | 1.3174 mL | |
| 50 mM | 0.0422 mL | 0.2108 mL | 0.4216 mL | 1.0539 mL | |
| 60 mM | 0.0351 mL | 0.1757 mL | 0.3513 mL | 0.8783 mL |