General Info
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-EDNRB (1-100) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | EDNRB |
Gene ID: | 1910 |
Uniprot ID: | EDNRB_HUMAN |
Immunogen Region: | 1-100 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human EDNRB (NP_001116131.1). |
Immunogen Sequence: | MQPPPSLCGRALVALVLACG LSRIWGEERGFPPDRATPLL QTAEIMTPPTKTLWPKGSNA SLARSLAPAEVPKGDRTAGS PPRTISPPPCQGPIEIKETF |
Description
Tissue Specificity | Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. |
Post Translational Modifications | Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405. |
Function | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
Protein Name | Endothelin Receptor Type BEt-BEt-BrEndothelin Receptor Non-Selective Type |
Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalized After Activation By Endothelins |
Alternative Antibody Names | Anti-Endothelin Receptor Type B antibodyAnti-Et-B antibodyAnti-Et-Br antibodyAnti-Endothelin Receptor Non-Selective Type antibodyAnti-EDNRB antibodyAnti-ETRB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance