Anti-CD120B Monoclonal Antibody

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2 which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.||Applications: |Suitable for use in ELISA, Flow Cytometry and Western Blot. Other applications not tested.||Recommended Dilution:|ELISA: 1:10,000|Flow Cytometry: 1:200-1:400|Western Blot: 1:500-1:2000|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.