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Signaling Pathways
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β-Interleukin I (163-171), human
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Immunology/Inflammation
β-Interleukin I (163-171), human
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β-Interleukin I (163-171), human
β-Interleukin I (163-171), human
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Background
β-Interleukin I (163-171), human(C39H64N12O19), a peptide with the sequence Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys, MW= 1005.Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). Interleukin 1 alpha and interleukin 1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis.
Interleukin-1 beta (IL-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
Figure1 Formula of b-Interleukin I (163-171), human
Figure2 Structure of b-Interleukin I
Ref:
1. Contassot E, Beer HD, French LE (2012). "Interleukin-1, inflammasomes, autoinflammation and the skin". Swiss Med Wkly142: w13590
2. Matzinger P (2012). "The evolution of the danget theory. Interview by Lauren Constable, Commissioning Editor". Expert Rev Clin Immunol8 (4): 311-7.
3. Sahoo M, Ceballos-Olvera I, del Barrio L, Re F (2011). "Role of the inflammasome, IL-1β, and IL-18 inbacterial infections". ScientificWorldJournal11: 2037-50.
Chemical Properties
Physical Appearance
A solid
Storage
Store at -20°C
M.Wt
1004.99
Cas No.
106021-96-9
Formula
C39H64N12O19
Synonyms
H2N-Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH
Solubility
insoluble in EtOH; ≥100.4 mg/mL in DMSO; ≥24.75 mg/mL in H2O